My game saves suddenly becomes unplayable after I rerun the game

They were the saves playing with mods, it is ensured that no mod has been applyed or removed. I shuted the game down directly however, not by clicking "quit to desktop" on the menu. The problem might be generated by that. I reran the game and found my saves became all unplayable as if it was been removed or added any mods, and I found on the mod management one mod disappeared and automaticlly comes back.

 

Please, I need support urgently. The mod were random maps reforged, 4th-level-abilites and laser beam.

I could find somewhere to upload the save if it is required.